No more ESKAPE

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America.

The Infectious Diseases Society of America (IDSA) continues to view with concern the lean pipeline for novel therapeutics to treat drug-resistant infections, especially those caused by gram-negative pathogens. Infections now occur that are resistant to all current antibacterial options. Although the IDSA is encouraged by the prospect of success for some agents currently in preclinical developme...

Centrosomes: Central no more?

It has recently been found that the zygotic development of a morphologically normal fly can occur without properly functioning mitotic centrosomes. Does this mean that centrosomes are not required for cell division in animals at all?

No More Scapegoating

Behavioral software contracts supplement interface information with logical assertions. A rigorous enforcement of contracts provides useful feedback to developers if it signals contract violations as soon as they occur and if it assigns blame to violators with precise explanations. Correct blame assignment gets programmers started with the debugging process and can significantly decrease the ti...

Schizophrenia: inorganic no more.

No more free lunches.

Free pens and pizza lunches. Sponsored conferences and compromised medical education. Courtesy golf and unaffordable holidays. Thought leaders and ghost writers. These are the trappings of doctors and drug companies being entwined in an embrace of avarice and excess, an embrace that distorts medical information and patient care. An article in this theme issue of the BMJ identifies 16 ways in wh...